Journal of Basic and Clinical Reproductive Sciences

Journal of Basic and Clinical Reproductive Sciences

The Effects of Sertraline on Premenstrual Tension Syndrome

Author(s): Mohamed Mk*, EL- Gharib MN and Dawood AS

Background: Premenstrual Dysphoric disorder (PMDD) is a serious kind of premenstrual syndrome (PMS) that causes significant distress and interferes with normal operation. PMS disturbs about 75% of women of reproductive age.
Aim: The purpose of this work is to test the effect of Sertraline, Selective Serotonin Reuptake Inhibitors on electroencephalographic (EEG) patterns, and clinical manifestations in females with premenstrual tension syndrome.
Patients and methods: This prospective observational study was conducted on 200 female participants. Patients will be subdivided into two groups: Group A (control): includes 80 normal females and Group B consists of 120 patients with PMS. Patients with PMS were given sertraline 50 mg/day orally, initiated 14 days before the expected onset of menses and discontinued the day menses began. All patients were admitted in the study was less than 35 years old, have a BMI between 20 and 30, having regular cycles, not using drugs. The following methods were undertaken for each patient: Full history. Complete clinical examination, EEG was done twice for each patient, firstly, on the 7th day of the cycle (follicular phase) and secondly on day 21 of the cycle (luteal phase).
The results: The present study confirmed the presence of a significant difference in frontal alpha asymmetry between PMS and non-PMS women. Moreover, we found that sertraline has no significant effects on EEG findings, but relieved the clinical symptoms.
Conclusions: We strongly support the effectiveness of SSRIs in the treatment of PMS.


Annals of Medical and Health Sciences Research Journal of Basic and Clinical Reproductive Sciences a publication of Society of Reproductive Biologist of Nigeria, is a peer-reviewed online journal with Semiannual print on demand compilation of issues published.
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