Journal of Basic and Clinical Reproductive Sciences

Journal of Basic and Clinical Reproductive Sciences
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The effects of bacterial infection on sperm DNA integrity, nuclear protamine, sperm quality and ICSI outcome

Author(s): Ali M Zeyad

In this study 120 semen samples were collected from unselected male partners of couples consulting in infertility and obstetrics clinic. All the samples were screened bacteriologically according to World Health Organization guidelines as well as sperm parameters and DNA fragmentation was evaluated. The protamines P1 and P2 concentrations were quantified using acid urea acrylamide gel electrophoresis. 84 couples underwent for ICSI treatment. The Effects of Bacterial Infection on Sperm Parameters The presence of bacteria might alter the sperm quality. Microbial infections have been reported to reduce sperm viability. Microorganisms might affect the male reproductive function in different ways: 1) Some pathogenic bacterial strains present in semen may act directly on sperm cells causing the agglutination of motile sperm, reducing the ability for the acrosome reaction, and also causing alterations in cell morphology. For example E. coli strains are known for their ability to immobilize and damage the morphology of spermatozoa by direct contact, mediated by attachment organelles such as pili or type-1 fimbriae (projections) and mannose receptor-dependent interactions. Also, the sperm surface is rich in glycoproteins and is therefore susceptible to the nitration of bacteria such as E. coli, C. trachomatis, U. urealyticum, Staphylococcus haemolyticus and Bacteroides ureolyticus with spermatozoa leading to the loss of sperm motility and normal morphology (1). Some researchers were isolated the spermagglutination factor from S. aureus, which showed spermagglutinating and spermicidal properties in vitro

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