Recurrent pregnancy loss is an intense personal calamity to the couples and an arduous clinical challenge to the Obstetricians.
When to evaluate and what constitutes a complete evaluation is still a state of flux. It is justifiable to investigate a couple for cause of pregnancy loss particularly if the female’s age is more than 35 years or has history of difficult conception. Women with two pregnancy losses have identifiable losses just as frequently as the one with three losses.
While Royal College of Obstetricians and Gynaecologists (RCOG, 2011) has defined Recurrent pregnancy loss (RPL) as the loss of three or more consecutive pregnancies, American Society of Reproductive Medicine (ASRM,2012) and European Society for Human Reproduction and Embryology (ESHRE,2017) has recently given definition of RPL as two or more clinical and consecutive pregnancy losses with either ultrasound or histopathological documentation, with exclusion of ectopic and molar pregnancies[3,4]. Thus we should start evaluating the couple after two losses.