Case Reports - Journal of Basic and Clinical Reproductive Sciences (2019) Volume 8, Issue 1
Caesarean Scar Pregnancy: A Diagnostic and Therapeutic Dilemma - A Case Report.
Received: 20-Dec-2018 Accepted Date: Jan 02, 2019 ; Published: 22-Jan-2019
Citation: Sonowal C Caesarean Scar Pregnancy: A Diagnostic and Therapeutic Dilemma-A Case Report doi: 10.4103/2278-960X.194516
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Introduction: With the increasing caesarean delivery rates, the risk of caesarean scar pregnancy is increasing. However, owing to its rarity, it poses as a diagnostic and therapeutic dilemma for the obstetrician.
Case report: A 33 year old lady G3P1L1A1 at 8 weeks 3 days period of gestation was diagnosed as a case of viable caesarean scar pregnancy. She was treated with intracardiac potassium chloride, and intragestational sac and placental Methotrexate injection. She was followed up and at 12 weeks post treatment serum β HCG normalized and endometrial cavity was empty on transvaginal sonography.
Conclusion: Diagnosis of caesarean scar pregnancy is difficult, but transvaginal sonography and colour flow Doppler may be helpful. Though the best and standard management is still unclear for this condition, the use of intracardiac KCl, and intra sac and placental Methotrexate can be considered in cases of viable caesarean scar pregnancy.
Scar pregnancy, Caesarean scar pregnancy, Intracardiac KCl, Methotrexate.
With the increasing caesarean delivery rates, apart from the risk of pathologically adherent placenta, the risk of another entity of implantation of gestational sac into the myometrium of hysterotomy scar, called as caesarean scar pregnancy is increasing. The reported incidence is 1/1800 to 1/2216 of all caesarean deliveries. The case reported here describes the use of intracardiac Potassium chloride, and intragestational sac and placental Methotrexate injection in a viable Caesarean scar pregnancy and its follow up.
A 33 year old lady, G3P1L1A1 came to casualty at 8 weeks 3 days period of gestation with a transabdominal sonography reporting a suspected scar pregnancy. She had history of one episode of sudden onset dull aching pain in lower abdomen which subsided on its own. She had no other complaints. She had history of abortifacient intake 4 days before. Her obstetric history included a full term uneventful caesarean section 12 years back and a spontaneous abortion 3 years back at 1½ months amenorrhea not followed by evacuation.
On admission, her general physical and systemic examination was normal. On per vaginal examination, uterus was 8 weeks size, anteverted, soft, mobile and bilateral fornices were free and non-tender. Her serum βHCG was 98,280 mIU/ml. A diagnosis of caesarean scar pregnancy was made on the basis of TVS showing-
1) Gestational sac of 3.3 × 3.8 × 3.2 cm corresponding to 10+2 weeks gestation with cardiac activity in the lower uterine segment at the site of previous caesarean scar (Figure 1),
Figure 1: (A) Transabdominal ultrasound showing a gestational sac in the lower uterine cavity adjacent to the previous scar with thinning of anterior myometrium. (B) Transvaginal scan with colour flow Doppler showing vascularity around the gestational sac. (C) Transvaginal scans showing a gestational sac in the lower uterine cavity adjacent to the previous scar with thinning of anterior myometrium.
2) Thin anterior myometrium (3 mm thickness) with a beak like projection from the sac into the myometrium,
3) Increased vascularity in the adjoining myometrium.
Initially, injection Methotrexate 50 mg intramuscularly was administered and TVS on the fourth day showed a gestational sac of 10 weeks with cardiac activity. After 3 days, TVS still showed a viable pregnancy. So under TVS guidance, 1.1 ml of 2 mmol/ml of potassium chloride was instilled into the fetal heart through a 20 gauge ovum aspiration needle. Injection Methotrexate 25 mg was instilled into the amniotic sac and placenta each. The fetus was observed for 5 minutes for confirming absence of cardiac activity. The patient was discharged on day 5th without complications and advised to follow up with weekly serum β HCG reports.
One week after this procedure, serum β HCG dropped to 6691 mIU/ml and TVS showed residual products of conception in the previous sac site. Serum β HCG continued to show falling trend and normalized on day 84th (12 weeks) following treatment and TVS showed an empty endometrial cavity.
Caesarean scar pregnancy, though rare, is a potentially life threatening condition. The exact cause of this entity has not been understood. However, many hypotheses have been proposed and one of them is that the conceptus enters into the myometrium through a microscopic tract between the prior caesarean scar and the endometrial canal. Early detection and treatment is necessary to avoid complications like uterine rupture, maternal mortality or adverse impacts on future fertility due to hysterectomy. Diagnosis is difficult but transvaginal sonography and colour flow Doppler using the following criteria may be helpful.
• Visualization of an empty uterine cavity as well as an empty endocervical canal
• Detection of the placenta and/or a gestational sac embedded in the hysterotomy scar
• A thin or absent myometrial layer between the gestational sac and the bladder
• A closed and empty cervical canal
• The presence of embryonic or fetal pole or yolk sac with or without cardiac activity
• The presence of prominent or rich vascular pattern in the area of caesarean scar.
Other diagnostic modalities are magnetic resonance imaging, hysteroscopy, laparoscopy or laparotomy. Hysterectomy may be required because of the risk of uterine rupture and uncontrolled bleeding. However, conservative treatments have been tried to preserve future fertility like local and systemic Methotrexate injection. In a case reported by Tulpin et al., local methotrexate injection was followed by uterine artery embolization to successfully treat a caesarean scar pregnancy. Lee et al. reported another case wherein they successfully treated a caesarean scar pregnancy at 9+3 weeks with bilateral uterine artery embolization followed by local injection of KCl and Methotrexate under sonographic guidance. In a retrospective case series by Timor–Tritsch et al., 19 patients with caesarean scar pregnancy were successfuly treated with combined intra muscular and intragestational methotrexate injection. In another case series by Pirjani et al., caesarean scar pregnancies were successfully treated with a combination of systemic methotrexate and local methotrexate or KCl. Though the best and standard management is still unclear for this condition, the use of intracardiac KCl, and intra sac and placental Methotrexate can be considered in cases of viable Caesarean scar pregnancy.
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