Journal of Basic and Clinical Reproductive Sciences

Journal of Basic and Clinical Reproductive Sciences
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Testicular Microstructure and Hormonal Profilae Following HAART Administration: The Role of Jatropha Tanjorensis

Author(s): Enobong I Bassey *, Innocent A Edagha, Aquaisua N Aquaisua, Annie F Archibong

Africa is endemic to the human immunodeficiency virus, acquired immunodeficiency syndrome(HIV/AIDS). In rural settings, the use of orthodox medicine with herbal medication is common. The efficacy of highly active antiretroviral therapy (HAART) has led to increased demand for its therapeutic use although reported to induce structural abnormalities in testicular tissues among other complications. Jatropha tanjorensis (JT) leaf has been reportedly for its numerous benefits which include; antioxidant, anti-anemic and spermatogenic potentials. This study investigated the alterations in testosterone and testis microstructure following the administration of HAART(Zidovudine, Lamivudine and Levirapine [ZLN]), JT ethanolic leaf extract and the concomitant administration of ZLN and JT using in vivo model. Twenty male Wistar rats weighing 163-267 g were allotted into 4 groups of 5 rats per group. Animals were fed with growers’pellet and provided water ad libitum. Group 1 served received placebo; group 2 received JT 670.8 mg; group 3 received ZLN 9.285 mg while group 4 received a combination of JT 670.8 mg and ZLN 9.285 mg per kg body weight respectively. All administrations were performed via oro-gavage for 7 days. On day 8, animals were humanely sacrificed under chloroform inhalation; with blood obtained for hormonal assay while the testes were harvested, weighed and processed for routine histology. Testicular histo-architecture revealed mild distortions in the seminiferous tubules of test groups, with significantly (p<0.05) increased testosterone compared to control. In conclusion concomitant administration of ZLN and JT possess testiculo-toxic potential.

Select your language of interest to view the total content in your interested language

20+ Million Readerbase
Google Scholar citation report
Citations : 1261

Journal of Basic and Clinical Reproductive Sciences received 1261 citations as per google scholar report

Journal of Basic and Clinical Reproductive Sciences peer review process verified at publons
Indexed In
  • Google Scholar
  • Publons
  • Euro Pub
Submit your Manuscript

  • Flexible online submission
  • Preliminary quality report within 3 days
  • 21 days rapid peer-review
  • High visibility of published content
  • Associated with relevant global conferences
  • 24/7 Editorial office availability