Journal of Basic and Clinical Reproductive Sciences

Journal of Basic and Clinical Reproductive Sciences

Gender Based Changes in Cord Blood Heme Oxygenase-1

Author(s): Kharb S*

Evidences support the role for the heme oxygenase system (HO-1) in the maintenance of a healthy pregnancy, especially during pathological challenge. To study gender-based changes in HO-1 levels in cord blood by comparing the concentrations of heme oxygenase-1 in maternal and cord blood venous sample of normotensive pregnant and preeclamptic women. Fifty pregnant women were selected and grouped as group 1 (control, n=25) comprising of normotensive women immediately after delivery; Group 2 (study group, n=25) comprising of age-and sex-matched preeclamptic women. Study samples were drawn (maternal venous blood and umbilical cord blood) and heme oxygenase-1 was analyzed by competitive enzyme linked immunosorbent assay. There was significant rise in serum heme oxygenase 1 levels in preeclamptic women as compared to normotensive pregnant women (p<0.001). Cord blood hemeoxygenase-1 levels in preeclamptic women were also significantly higher than normotensive counterpart (p<0.001).The cord blood heme oxygenase-1 levels in both the groups were comparable with their maternal levels. Maternal HO-1 were higher in mothers with female babies as compared to male (285.30 ± 28.40 ng/ml vs. 268.41 ± 35.00 ng/ml, p>0.05) in group I. Maternal HO-1 were higher in preeclamptic mothers with female babies as compared to male counter parts in group II (580 ± 111.28 ng/ml vs. 526.2 ± 74.3 ng/ml, p>0.05 ). Cord blood HO-1 were higher in female babies as compared to male babies in group I (279.23 ± 30.9 5 ng/ml vs. 273.75 ± 33.45 ng/ml, p>0.05). Cord blood HO-1 were higher in females as compared to male in group II (560.83 ± 67.33 ng/ml vs. 534.89 ± 63.76 ng/ml, p>0.05). Demonstration of gender based changes in the present study supports the idea of active contribution of placenta to maternal metabolism during pregnancy.


Annals of Medical and Health Sciences Research Journal of Basic and Clinical Reproductive Sciences a publication of Society of Reproductive Biologist of Nigeria, is a peer-reviewed online journal with Semiannual print on demand compilation of issues published.
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