Journal of Basic and Clinical Reproductive Sciences

Journal of Basic and Clinical Reproductive Sciences
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

A Review on the Incidence, Interaction, and Future Perspective on Zika Virus

Author(s): Lukman Olalekan Afolabi, Musbahu Muhammad Sani, Wahab Oluwanisola Okunowo

Zika virus (ZIKV) belongs to the family Flaviviridae and genus Flavivirus. It is a single‑stranded positive‑sense ribonucleic acid (RNA) virus, has its origin traced to Zika forest in Uganda. Its infection leads to ZIKV fever, characterized by arthralgia, myalgia, rash, conjunctivitis, and asthenia. Clinical presentation of the infection is nonspecific and may often be confused with symptoms of other flaviviral diseases (dengue, West Nile [WN], and chikungunya). Recently, ZIKV has been associated with congenital malformations and neurological complications such as microcephaly and Guillain–Barre’ syndrome. The viral tropism revealed an infection of the skin fibroblasts, keratinocytes, and immature dendritic cells through enhanced expression of dendritic cell‑specific intracellular adhesion molecule 3‑grabbing nonintegrin or anexelecto (Greekword: 'uncontrolled’) and tyrosine protein kinase receptor 3 systems. Silencing of T‑cell immunoglobulin (Ig) and mucin domain 1 (TIM‑1) and AXL RNAs has shown blockage of viral entry through their anti‑TIM‑1 and anti‑AXL antibodies, hence serving as a potential target for ZIKV drug development. Biotechnological approaches targeted toward ZIKV vector control include the development of transgenic mosquitoes to disrupt the genome pool of wild strains and use of an endosymbiotic bacterium to prevent replication of arboviruses within its vector. Other approaches include the use of gene drive and exploration of the genetic redundancy to disrupt the receptors used by the virus to gain entry into its host. It is also imperative to explore the modality through which neutralizing antibodies block this viral infection as this may prove as a potential target to arrest the viral life cycle.


Select your language of interest to view the total content in your interested language

20+ Million Readerbase
Google Scholar citation report
Citations : 1261

Journal of Basic and Clinical Reproductive Sciences received 1261 citations as per google scholar report

Journal of Basic and Clinical Reproductive Sciences peer review process verified at publons
Indexed In
  • Google Scholar
  • Publons
  • Euro Pub
Submit your Manuscript

  • Flexible online submission
  • Preliminary quality report within 3 days
  • 21 days rapid peer-review
  • High visibility of published content
  • Associated with relevant global conferences
  • 24/7 Editorial office availability